New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

AA Getu, A Tigabu, M Zhou, J Lu, Ø Fodstad, M Tan - Molecular Cancer, 2023 - Springer
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …

Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem

W Luo - Theranostics, 2023 - pmc.ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

Efficient NIR-II type-I AIE photosensitizer for mitochondria-targeted photodynamic therapy through synergistic apoptosis–ferroptosis

J Zhuang, B Wang, H Chen, K Zhang, N Li, N Zhao… - ACS …, 2023 - ACS Publications
Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for
photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological …

Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy

R Zhao, Y Zhu, L Feng, B Liu, Y Hu, H Zhu… - Advanced …, 2024 - Wiley Online Library
Taking the significance of the special microenvironment for tumor cell survival into account,
disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy …

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

P Lee, NS Chandel, MC Simon - Nature reviews Molecular cell biology, 2020 - nature.com
Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

The role of ubiquitination in tumorigenesis and targeted drug discovery

L Deng, T Meng, L Chen, W Wei, P Wang - Signal transduction and …, 2020 - nature.com
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Advances in application of azobenzene as a trigger in biomedicine: molecular design and spontaneous assembly

HB Cheng, S Zhang, J Qi, XJ Liang… - Advanced …, 2021 - Wiley Online Library
Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has
shown superior performance as a functional material in biomedical applications. The results …

Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

G Berumen Sánchez, KE Bunn, HH Pua… - Cell Communication and …, 2021 - Springer
Intercellular communication is a critical process that ensures cooperation between distinct
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …

Recent progress and trends in X-ray-induced photodynamic therapy with low radiation doses

L He, X Yu, W Li - ACS nano, 2022 - ACS Publications
The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires
innovative solutions for its congenitally deficient shadow penetration of the visible-light …

Tailoring photosensitive ROS for advanced photodynamic therapy

DL Sai, J Lee, DL Nguyen, YP Kim - Experimental & molecular …, 2021 - nature.com
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …