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New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem
W Luo - Theranostics, 2023 - pmc.ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
Efficient NIR-II type-I AIE photosensitizer for mitochondria-targeted photodynamic therapy through synergistic apoptosis–ferroptosis
J Zhuang, B Wang, H Chen, K Zhang, N Li, N Zhao… - ACS …, 2023 - ACS Publications
Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for
photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological …
photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological …
Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy
R Zhao, Y Zhu, L Feng, B Liu, Y Hu, H Zhu… - Advanced …, 2024 - Wiley Online Library
Taking the significance of the special microenvironment for tumor cell survival into account,
disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy …
disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy …
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …
The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
Advances in application of azobenzene as a trigger in biomedicine: molecular design and spontaneous assembly
HB Cheng, S Zhang, J Qi, XJ Liang… - Advanced …, 2021 - Wiley Online Library
Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has
shown superior performance as a functional material in biomedical applications. The results …
shown superior performance as a functional material in biomedical applications. The results …
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease
G Berumen Sánchez, KE Bunn, HH Pua… - Cell Communication and …, 2021 - Springer
Intercellular communication is a critical process that ensures cooperation between distinct
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …
cell types and maintains homeostasis. EVs, which were initially described as cellular debris …
Recent progress and trends in X-ray-induced photodynamic therapy with low radiation doses
The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires
innovative solutions for its congenitally deficient shadow penetration of the visible-light …
innovative solutions for its congenitally deficient shadow penetration of the visible-light …
Tailoring photosensitive ROS for advanced photodynamic therapy
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …
modality for tumor treatment. However, the complexity of tumor microenvironments poses …