High inter-patient variability and high spatial heterogeneity are features of colorectal cancer
(CRC). This may influence the molecular characterization of tumor tissue, now mandatory for …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

The most recent version of the European Society for Medical Oncology (ESMO) consensus
guidelines for the treatment of patients with metastatic colorectal cancer (mCRC) was …

Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …

Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …

Background The use of biomarkers to target anti-EGFR treatments for metastatic colorectal
cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic …

Metastasis is a complex biological process that has been difficult to delineate in human
colorectal cancer (CRC) patients. A major obstacle in understanding metastatic lineages is …

Chromosomal instability (CIN) is one of the major forms of genomic instability in various
human cancers and is recognized as a common hallmark of tumorigenesis and …

Background High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of
ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although …

Circulating tumour DNA (ctDNA) has the potential to be a specific biomarker for the
monitoring of tumours in patients with colorectal cancer (CRC). Here, our aim was to …