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Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2
MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes
Arthrospira platensis (A. platensis) aqueous extract has massive amounts of natural
products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc …
products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc …
[HTML][HTML] Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes (3CLpro, PLpro and NSP15) by molecular docking and molecular dynamics …
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-
2 infection, there is an urgent unmet medical need to identify novel and effective approaches …
2 infection, there is an urgent unmet medical need to identify novel and effective approaches …
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
Discovery of procyanidin condensed tannins of (−)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2
S Sureram, N Chutiwitoonchai, T Pooprasert… - International journal of …, 2024 - Elsevier
Kratom, Mitragyna speciosa, is one of the most popular herbs in the West and Southeast
Asia. A number of previous works have focused on bioactive alkaloids in this plant; however …
Asia. A number of previous works have focused on bioactive alkaloids in this plant; however …
[HTML][HTML] Natural bioactive molecules: an alternative approach to the treatment and control of COVID-19
Several coronaviruses (CoVs) have been associated with serious health hazards in recent
decades, resulting in the deaths of thousands around the globe. The recent coronavirus …
decades, resulting in the deaths of thousands around the globe. The recent coronavirus …
Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
[HTML][HTML] Commercially available flavonols are better SARS-CoV-2 inhibitors than isoflavone and flavones
OA Chaves, N Fintelman-Rodrigues, X Wang… - Viruses, 2022 - mdpi.com
Despite the fast development of vaccines, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the …
(SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the …
Pharmacologic Activities of Plant‐Derived Natural Products on Respiratory Diseases and Inflammations
D Timalsina, KP Pokhrel… - BioMed Research …, 2021 - Wiley Online Library
Respiratory inflammation is caused by an air‐mediated disease induced by polluted air,
smoke, bacteria, and viruses. The COVID‐19 pandemic is also a kind of respiratory disease …
smoke, bacteria, and viruses. The COVID‐19 pandemic is also a kind of respiratory disease …
Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis
The Amaryllidaceae species are well-known as a rich source of bioactive compounds in
nature. Although Hymenocallis littoralis has been studied for decades, its polar components …
nature. Although Hymenocallis littoralis has been studied for decades, its polar components …