Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2

MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …

Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes

OA ElFar, N Billa, HR Lim, KW Chew, WY Cheah… - …, 2022 - Taylor & Francis
Arthrospira platensis (A. platensis) aqueous extract has massive amounts of natural
products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc …

[HTML][HTML] Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes (3CLpro, PLpro and NSP15) by molecular docking and molecular dynamics …

R Zrieq, I Ahmad, M Snoussi, E Noumi, M Iriti… - International Journal of …, 2021 - mdpi.com
Considering the current dramatic and fatal situation due to the high spreading of SARS-CoV-
2 infection, there is an urgent unmet medical need to identify novel and effective approaches …

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

Discovery of procyanidin condensed tannins of (−)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2

S Sureram, N Chutiwitoonchai, T Pooprasert… - International journal of …, 2024 - Elsevier
Kratom, Mitragyna speciosa, is one of the most popular herbs in the West and Southeast
Asia. A number of previous works have focused on bioactive alkaloids in this plant; however …

[HTML][HTML] Natural bioactive molecules: an alternative approach to the treatment and control of COVID-19

F Islam, S Bibi, AFK Meem, MM Islam… - International Journal of …, 2021 - mdpi.com
Several coronaviruses (CoVs) have been associated with serious health hazards in recent
decades, resulting in the deaths of thousands around the globe. The recent coronavirus …

Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …

H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …

[HTML][HTML] Commercially available flavonols are better SARS-CoV-2 inhibitors than isoflavone and flavones

OA Chaves, N Fintelman-Rodrigues, X Wang… - Viruses, 2022 - mdpi.com
Despite the fast development of vaccines, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the …

Pharmacologic Activities of Plant‐Derived Natural Products on Respiratory Diseases and Inflammations

D Timalsina, KP Pokhrel… - BioMed Research …, 2021 - Wiley Online Library
Respiratory inflammation is caused by an air‐mediated disease induced by polluted air,
smoke, bacteria, and viruses. The COVID‐19 pandemic is also a kind of respiratory disease …

Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

NTH Le, S De Jonghe, K Erven, T Vermeyen, AM Baldé… - Molecules, 2023 - mdpi.com
The Amaryllidaceae species are well-known as a rich source of bioactive compounds in
nature. Although Hymenocallis littoralis has been studied for decades, its polar components …