IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …
system. They profoundly participate in immune responses during infection and inflammation …
Therapeutic opportunities of the IL-22–IL-22R1 system
R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24
Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
Cytokines: key determinants of resistance or disease progression in visceral leishmaniasis: opportunities for novel diagnostics and immunotherapy
Leishmaniasis is a parasitic disease of humans, highly prevalent in parts of the tropics,
subtropics, and southern Europe. The disease mainly occurs in three different clinical forms …
subtropics, and southern Europe. The disease mainly occurs in three different clinical forms …
The interleukin-10 family of cytokines and their role in the CNS
Resident cells of the central nervous system (CNS) play an important role in detecting insults
and initiating protective or sometimes detrimental host immunity. At peripheral sites, immune …
and initiating protective or sometimes detrimental host immunity. At peripheral sites, immune …
The biological functions of T helper 17 cell effector cytokines in inflammation
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …
The innate immune system in acute and chronic wounds
AS MacLeod, JN Mansbridge - Advances in wound care, 2016 - liebertpub.com
Significance: This review article provides an overview of the critical roles of the innate
immune system to wound healing. It explores aspects of dysregulation of individual innate …
immune system to wound healing. It explores aspects of dysregulation of individual innate …
Interleukin-10 and related cytokines and receptors
S Pestka, CD Krause, D Sarkar, MR Walter… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …