The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …

Unresolved low grade systemic inflammation represents the underlying pathological
mechanism driving immune and metabolic pathways involved in autoimmune diseases …

Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is
clinically characterised by small patches of baldness on the scalp and/or around the body. It …

Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4+
T cells play an essential role. CD4+ T cells rely on glycolysis for inflammatory effector …

Inhalation of dust containing crystalline silica is associated with a number of acute and
chronic diseases including systemic autoimmune diseases. Evidence for the link with …

Context Chronic systemic inflammation in obesity originates from local immune responses in
visceral adipose tissue. However, assessment of a broad range of inflammation-mediating …

Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …