Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
The hallmarks of cancer immune evasion
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
The evolution of non-small cell lung cancer metastases in TRACERx
Metastatic disease is responsible for the majority of cancer-related deaths. We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …
A pan-cancer compendium of chromosomal instability
Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …
Cancer evolution: Darwin and beyond
Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
Genomic–transcriptomic evolution in lung cancer and metastasis
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we …
and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we …
Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
Multi-stage mechanisms of tumor metastasis and therapeutic strategies
Z Liu, J Chen, Y Ren, S Liu, Y Ba, A Zuo… - … and Targeted Therapy, 2024 - nature.com
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …
numerous phases of the disease and progress under intense evolutionary pressures. Organ …