White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

The escalating prevalence of individuals becoming overweight and obese is a rapidly rising
global health problem, placing an enormous burden on health and economic systems …

Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …

Background Recent technological advances have introduced novel methods for measuring
body composition, each with unique benefits and limitations. The choice of method often …

Obesity is increasingly becoming a prevalent health concern among adolescents, leading to
significant risks like cardiometabolic diseases (CMDs). The early discovery and diagnosis of …

Inter-individual variation in fat distribution is increasingly recognized as clinically important
but is not routinely assessed in clinical practice, in part because medical imaging has not …

Electronic health records are often incomplete, reducing the power of genetic association
studies. For some diseases, such as knee osteoarthritis where the routine course of …

Background The fatty liver index (FLI) is frequently used as a non-invasive clinical marker for
research, prognostic and diagnostic purposes. It is also used to stratify individuals with …

The human skeletal form underlies our ability to walk on two legs, but unlike standing height,
the genetic basis of limb lengths and skeletal proportions is less well understood. Here we …