Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Parkinson disease-associated cognitive impairment

D Aarsland, L Batzu, GM Halliday… - Nature reviews Disease …, 2021 - nature.com
Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …

Parkinson's disease

BR Bloem, MS Okun, C Klein - The Lancet, 2021 - thelancet.com
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Parkinson's disease: etiopathogenesis and treatment

J Jankovic, EK Tan - Journal of Neurology, Neurosurgery & Psychiatry, 2020 - jnnp.bmj.com
The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …

Medical, surgical, and physical treatments for Parkinson's disease

T Foltynie, V Bruno, S Fox, AA Kühn, F Lindop, AJ Lees - The Lancet, 2024 - thelancet.com
Although dopamine replacement therapy remains a core component of Parkinson's disease
treatment, the onset of motor fluctuations and dyskinetic movements might require a range of …

Diagnosis and treatment of Parkinson disease: a review

MJ Armstrong, MS Okun - Jama, 2020 - jamanetwork.com
Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

V Maini Rekdal, EN Bess, JE Bisanz, PJ Turnbaugh… - Science, 2019 - science.org
INTRODUCTION Parkinson's disease is a debilitating neurological condition affecting more
than 1% of the global population aged 60 and above. The primary medication used to treat …

Monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: past, present, and future

YY Tan, P Jenner, SD Chen - Journal of Parkinson's disease, 2022 - journals.sagepub.com
Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment
of Parkinson's disease (PD). MAO-B inhibitor monotherapy has been shown to be effective …

International Parkinson and movement disorder society evidence‐based medicine review: update on treatments for the motor symptoms of Parkinson's disease

SH Fox, R Katzenschlager, SY Lim, B Barton… - Movement …, 2018 - Wiley Online Library
Objective: The objective of this review was to update evidence‐based medicine
recommendations for treating motor symptoms of Parkinson's disease (PD). Background …

Potentially inadequate medications in the elderly: PRISCUS 2.0: first update of the PRISCUS list

NK Mann, T Mathes, A Sönnichsen… - Deutsches …, 2023 - pmc.ncbi.nlm.nih.gov
Background The term potentially inadequate medication (PIM) is used to describe
substances that may be unsuitable for use in the elderly and should be avoided. The …