Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Acetate, the shortest chain fatty acid, has been implicated in providing health benefits
whether it is derived from the diet or is generated from microbial fermentation of fiber in the …

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …

Abstract Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA
synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A …

Alkylating chemotherapy is a central component of the management of glioblastoma (GBM).
Among the factors that regulate the response to alkylation damage, NF-κB acts to both …

Background: Abnormal energy metabolism is often documented in the brain of patients and
rodents with depression. In metabolic stress, acetate serves as an important source of acetyl …

The response of patients with gliomas to alkylating chemotherapy is heterogeneous.
However, there are currently no universally accepted predictors of patient response to these …

Glioblastoma is the most common and aggressive primary tumor in the central nervous
system, accounting for 12%–15% of all brain tumors. 3-O-Acetyl-11-keto-β-boswellic acid …

Tumors rely on multiple nutrients to meet cellular bioenergetics and macromolecular
synthesis demands of rapidly dividing cells. Although the role of glucose and glutamine in …