In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein
phosphorylation and calcium signaling cascades, where it provides an essential nodal point …

Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with
ventricular dilation and markedly reduced systolic function, heart failure with preserved …

Background: The sarcoplasmic reticulum (SR) Ca2+-ATPase 2 (SERCA2) mediates Ca2+
reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine …

Although the presence of cardiac dysfunction and cardiomyopathy in chronic diabetes has
been recognized, the pathophysiology of diabetes-induced metabolic and subcellular …

Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …

The β2 adrenergic receptor (β2AR) signals through both Gs and Gi in cardiac myocytes, and
the Gi pathway counteracts the Gs pathway. However, Gi coupling is much less efficient than …

Heart failure (HF) presents a significant clinical challenge, with current treatments mainly
easing symptoms without stop** disease progression. The targeting of calcium (Ca2+) …

Background—Although resveratrol has multiple beneficial cardiovascular effects, whether
resveratrol can be used for the treatment and management of heart failure (HF) remains …

Although t-tubules have traditionally been thought to be absent in atrial cardiomyocytes,
recent studies have suggested that t-tubules exist in the atria of large mammals. However, it …