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Involvement of ENaC in the development of salt-sensitive hypertension
Salt-sensitive hypertension is associated with renal and vascular dysfunctions, which lead to
impaired fluid excretion, increased cardiac output, and total peripheral resistance. It is …
impaired fluid excretion, increased cardiac output, and total peripheral resistance. It is …
Evidence of the importance of Nox4 in production of hypertension in Dahl salt-sensitive rats
AW Cowley Jr, C Yang, NN Zheleznova… - …, 2016 - ahajournals.org
This study reports the consequences of knocking out NADPH (nicotinamide adenine
dinucleotide phosphate) oxidase 4 (Nox4) on the development of hypertension and kidney …
dinucleotide phosphate) oxidase 4 (Nox4) on the development of hypertension and kidney …
Renal glomerular mitochondria function in salt-sensitive hypertension
Salt-sensitive (SS) hypertension is accompanied with an early onset of proteinuria, which
results from the loss of glomerular podocytes. Here, we hypothesized that glomerular …
results from the loss of glomerular podocytes. Here, we hypothesized that glomerular …
[HTML][HTML] Mitochondrial dysfunction and altered renal metabolism in Dahl salt-sensitive rats
Z Wang, Q Sun, N Sun, M Liang, Z Tian - Kidney and Blood Pressure …, 2017 - karger.com
Background/Aims: The kidney plays a critical role in the control of blood pressure and its
elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy …
elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy …
Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats
NN Zheleznova, C Yang… - American Journal of …, 2016 - journals.physiology.org
Nox4 and Nox2 are the most abundant NADPH oxidases (Nox) in the kidney and have been
shown to contribute to hypertension, renal oxidative stress, and injury in Dahl salt-sensitive …
shown to contribute to hypertension, renal oxidative stress, and injury in Dahl salt-sensitive …
Optical metabolic imaging of irradiated rat heart exposed to ischemia–reperfusion injury
Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether
irradiation predisposes the heart to further ischemia and reperfusion (IR) injury is not well …
irradiation predisposes the heart to further ischemia and reperfusion (IR) injury is not well …
The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging
The relationships between oxidative stress in the hippocampus and other aging-related
changes such as hearing loss, cortical thinning, or changes in body weight are not yet …
changes such as hearing loss, cortical thinning, or changes in body weight are not yet …
Computational modeling of substrate-dependent mitochondrial respiration and bioenergetics in the heart and kidney cortex and outer medulla
Integrated computational modeling provides a mechanistic and quantitative framework to
characterize alterations in mitochondrial respiration and bioenergetics in response to …
characterize alterations in mitochondrial respiration and bioenergetics in response to …
Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and Its Alteration During Ischemia and …
Oxidation of substrates to generate ATP in mitochondria is mediated by redox reactions of
NADH and FADH2. Cardiac ischemia and reperfusion (IR) injury compromises …
NADH and FADH2. Cardiac ischemia and reperfusion (IR) injury compromises …
Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study
Previous studies have indicated that reactive oxygen species produced by NADPH oxidase
(Nox) are important risk factors of hypertension. The current study aims to examine the …
(Nox) are important risk factors of hypertension. The current study aims to examine the …