Short open reading frames (sORFs) are a common feature of all genomes, but their coding
potential has mostly been disregarded, partly because of the difficulty in determining …

Gene expression is finely regulated at the post-transcriptional level. Features of the
untranslated regions of mRNAs that control their translation, degradation and localization …

Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

The mechanism of initiation of translation differs between prokaryotes and eukaryotes, and
the strategies used for regulation differ accordingly. Translation in prokaryotes is usually …

Changes in gene expression are at the core of most biological processes, from cell
differentiation to organ development, including the adaptation of the whole organism to the …

There is growing interest in the role of translational regulation in cellular homeostasis during
organismal development. Translation initiation is the rate-limiting step in mRNA translation …

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway
in yeast when one or more amino acids become limiting for growth. GCN2's function in …

Transcription of protein-coding genes in trypanosomes is polycistronic and gene expression
is primarily regulated by post-transcriptional mechanisms. Sequence motifs in the …

Most of the phenotypic diversity that we perceive in the natural world is directly attributable to
the peculiar structure of the eukaryotic gene, which harbors numerous embellishments …

The silencing phenotype in Arabidopsis thaliana lines with an inverted repeat transgene
under the control of a phloem-specific promoter was manifested in regions around veins due …