During the past decade, small non-coding RNAs have rapidly emerged as important
contributors to gene regulation. To carry out their biological functions, these small RNAs …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

RNA silencing pathways convert the sequence information in long RNA, typically double-
stranded RNA, into∼ 21-nt RNA signaling molecules such as small interfering RNAs …

RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is
conserved in diverse eukaryotic species but has been lost in the model budding yeast …

Argonaute proteins were first discovered genetically, and extensive research in the past few
years has revealed that members of the Argonaute protein family are key players in gene …

The involvement of RNA interference (RNAi) in heterochromatin formation has become clear
largely through studies in the fission yeast Schizosaccharomyces pombe and plants like …

We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem
cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins that …

Double-stranded RNA has been shown to induce gene silencing in diverse eukaryotes and
by a variety of pathways. We have examined the taxonomic distribution and the phylogenetic …

Though they started out as somewhat mysterious components of the RNAi effector
complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They …

RNAi-mediated heterochromatin assembly in fission yeast requires the RNA-induced
transcriptional silencing (RITS) complex and a putative RNA-directed RNA polymerase …