The phenyl ring is a basic structural element in chemistry. Here, we show the design,
synthesis, and validation of its new saturated bioisostere with improved physicochemical …

The remarkable structural and electronic properties of rigid non-conjugated hydrocarbons
afford attractive opportunities to design molecular building blocks for both medicinal and …

Nucleic acid aptamers selected through systematic evolution of ligands by exponential
enrichment (SELEX) fold into exquisite globular structures in complex with protein targets …

A robust multigram-scale synthesis of 1, 3-disubstituted cubanes (previously only available
on milligram-scale) is reported. The approach exploits a readily available enone …

Abstract The spiro [3.3] heptane core, with the non‐coplanar exit vectors, was shown to be a
saturated benzene bioisostere. This scaffold was incorporated into the anticancer drug …

The highly strained cubane system is of great interest as a scaffold and rigid linker in both
pharmaceutical and materials chemistry. A straightforward approach is reported for the scale …

The Cambridge Structural Database was surveyed for crystals featuring I⋯ Br secondary-
bonding in their supramolecular assemblies occurring independently of other obvious …

We report a two‐step approach to obtain synthetically versatile bicyclo [1.1. 1] pentane
(BCP) derivatives using Grignard reagents. This method allows the incorporation of BCP …

The unique properties of rigid, nonconjugated hydrocarbons provide many opportunities to
design molecular building blocks for a variety of applications, but the development of …

Disubstituted cuneane has potential as ap‐disubstituted benzene bioisostere and a novel
chiral scaffold. It is a constitutional isomer of a 1, 4‐disubstituted cubane obtained via a …