Genetic, environmental and lifestyle determinants of accelerated telomere attrition as contributors to risk and severity of multiple sclerosis

M Hecker, J Bühring, B Fitzner, PS Rommer, UK Zettl - Biomolecules, 2021 - mdpi.com
Telomeres are protective structures at the ends of linear chromosomes. Shortened telomere
lengths (TL) are an indicator of premature biological aging and have been associated with a …

SeXX matters in multiple sclerosis

F Gilli, KD DiSano, AR Pachner - Frontiers in neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative
disease of the central nervous system (CNS). An interesting feature that this debilitating …

Development of an age‐adjusted model for blood neurofilament light chain

C Harp, GA Thanei, X Jia, J Kuhle… - Annals of clinical …, 2022 - Wiley Online Library
Objective To develop an age‐adjustment model for neurofilament light chain (NfL), an
emerging injury marker in patients with a range of neurologic conditions including multiple …

Endocannabinoid modulation in neurodegenerative diseases: In pursuit of certainty

A Vasincu, RN Rusu, DC Ababei, M Larion, W Bild… - Biology, 2022 - mdpi.com
Simple Summary Neurodegenerative diseases represent an important cause of morbidity
and mortality worldwide. Existing therapeutic options are limited and focus mostly on …

Th17-related cytokines as potential discriminatory markers between neuromyelitis optica (Devic's disease) and multiple sclerosis—A review

K Maciak, S Pietrasik, A Dziedzic, J Redlicka… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis (MS) and Devic's disease (NMO; neuromyelitis optica) are autoimmune,
inflammatory diseases of the central nervous system (CNS), the etiology of which remains …

Sex bias in multiple sclerosis and neuromyelitis optica spectrum disorders: how it influences clinical course, MRI parameters and prognosis

P Nytrova, O Dolezal - Frontiers in immunology, 2022 - frontiersin.org
This review is a condensed summary of representative articles addressing the sex/gender
bias in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). The …

Circulating miRNAs as potential biomarkers distinguishing relapsing–remitting from secondary progressive multiple sclerosis. A review

S Pietrasik, A Dziedzic, E Miller, M Starosta… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis (MS) is a debilitating neurodegenerative, highly heterogeneous disease
with a variable course. The most common MS subtype is relapsing–remitting (RR), having …

miR-146a and miR-155 as promising biomarkers for prognosis and diagnosis of multiple sclerosis: systematic review

S Rajabi, K Sadegi, S Hajisobhani, M Kaveh… - Egyptian Journal of …, 2024 - Springer
Background Small RNA molecules known as microRNAs (miRNAs) regulate gene
expression during the post-translational steps. miRNAs are essential for many physiological …

Sex and gender differences in autoimmune demyelinating CNS disorders: Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and myelin …

L Diem, H Hammer, R Hoepner, M Pistor… - International Review of …, 2022 - Elsevier
Multiple sclerosis (MS), Neuromyelitis optica spectrum disorder (NMOSD) and Myelin-
Oligodendrocyte-Glycoprotein antibody associated disorder (MOGAD) are demyelinating …

Immune cell contributors to the female sex bias in multiple sclerosis and experimental autoimmune encephalomyelitis

N Alvarez-Sanchez, SE Dunn - Sex Differences in Brain Function and …, 2022 - Springer
Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating disease of the central
nervous system (CNS) that leads to axonal damage and accumulation of disability …