Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

Increasing evidence suggests that mental health and physical health are linked by neural
systems that jointly regulate somatic physiology and high-level cognition. Key systems …

Research from recent decades has highlighted the distinction between excitatory and
inhibitory Pavlovian learning mechanisms. Based on this distinction, state-of-the-art …

The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …

Emotions are powerful determinants of behaviour, thought and experience, and they may be
regulated in various ways. Neuroimaging studies have implicated several brain regions in …

Through advances in both basic and clinical scientific research, Pavlovian fear conditioning
and extinction have become an exemplary translational model for understanding and …

The aim of the current study was twofold:(1) to systematically examine differences in fear
conditioning between anxiety patients and healthy controls using meta‐analytic methods …

The well-replicated observation that many people maintain mental health despite exposure
to severe psychological or physical adversity has ignited interest in the mechanisms that …

Progress in clinical and affective neuroscience is redefining psychiatric illness as
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …

Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …