Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Preparation of drug nanoparticles via wet media milling (nanomilling) is a very versatile drug
delivery platform and is suitable for oral, injectable, inhalable, and buccal applications. Wet …

In recent years, nanocrystal technology has been extensively investigated. Due to the
submicron particle size and unique physicochemical properties of nanocrystals, they …

Background: Respiratory diseases are mainly derived from acute and chronic inflammation
of the alveoli and bronchi. The pathophysiological mechanisms of pulmonary inflammation …

Ensuring the physical stability of drug nanosuspensions prepared via wet media milling has
been a challenge for pharmaceutical scientists. The aim of this study is to assess the …

Three-dimensional printing is promising in the pharmaceutical industry for personalized
medicine, on-demand production, tailored drug loading, etc. Pressure-assisted microsyringe …

Objective The current study sought to design a quickly dissolving, high drug loading
nanocrystal-based solid dispersion (NC-SD) in order to improve the dissolution of poorly …

Aqueous solubility of a drug substance is an important attribute affecting oral bioavailability.
Nanonization, particle size reduction to submicron level, is an elegant approach to improve …

Drug nanoparticles in suspensions can form aggregates leading to physical instability,
which is traditionally mitigated using soluble polymers and surfactants. The aim of this paper …

Abstract The US Food and Drug Administration (FDA) emphasizes drug product
development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD …