The small size of dendritic spines belies the elaborate role they play in excitatory synaptic
transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Protein molecules are highly diverse communication platforms and their interaction
repertoire stretches from atoms over small molecules such as sugars and lipids to …

Abstract Human Immunodeficiency Virus (HIV) is a progressive infection that targets the
immune system, affecting more than 37 million people around the world. While …

The PDZ family is comprised of small modular domains that play critical roles in the allosteric
modulation of many cellular signaling processes by binding to the C‐terminal tail of different …

The primary cause of cancer-related death from solid tumors is metastasis. While unraveling
the mechanisms of this complicated process continues, our ability to effectively target and …

Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is
involved in several pathologies, including neuropathic pain, but direct inhibition of AMPAR s …

Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is
the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin …

NMR spectroscopy has proven to be a key method for studying intrinsically disordered
proteins (IDPs). Nonetheless, traditional NMR methods developed for solving structures of …

PDZ domains are modular domains that conventionally bind to C terminal or internal motifs
of target proteins to control cellular functions through the regulation of protein complex …