The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …

The duplication of the eukaryotic genome is an intricate process that has to be tightly safe‐
guarded. One of the most frequently occurring errors during DNA synthesis is the mis …

RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-
Goutières syndrome (AGS), but the mechanisms triggering disease in the human central …

All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

Cellular senescence caused by oncogenic stimuli is associated with the development of
various age-related pathologies through the senescence-associated secretory phenotype …

Aicardi–Goutières syndrome (AGS) is a rare monogenic autoimmune disease that primarily
affects the brains of children patients. Its main clinical features include encephalatrophy …

Aicardi-Goutières syndrome (AGS) is a monogenic type I interferonopathy characterized by
neurodevelopmental defects and upregulation of type I interferon signaling and …

Classical DNA and RNA polymerase (pol) enzymes have defined roles with their respective
substrates, but several pols have been found to have multiple functions. We reported …

During the very early stages of embryonic development chromosome replication occurs
under rather challenging conditions, including a very short cell cycle, absence of …