The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments
through a variety of cytoskeletal linker proteins to mechanically connect intracellular and …

Vascular walls change their dimension and mechanical properties in response to injury such
as balloon angioplasty and endovascular stent implantation. Placement of bare metal stents …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Growth factors play a crucial role in information transfer between cells and their
microenvironment in tissue engineering and regeneration. They initiate their action by …

The ability to fabricate perfusable, small-diameter vasculature is a foundational step toward
generating human tissues/organs for clinical applications. Currently, it is highly challenging …