Introduction 3. Discussion 3.1. G1/S control in mammalian cells: the basic model 3.2. Cdk4/6-
cyclin D in mouse development and cell proliferation 3.2. 1. Individual D-cyclins are …

Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes.
From yeast to humans, cell cycle progression and cell division require the activation of a …

The ARID is an ancient DNA-binding domain that is conserved throughout the evolution of
higher eukaryotes. The ARID consensus sequence spans about 100 amino acid residues …

Abstract Cyclin‐dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment
of cancer. Development of CDK2 inhibitors has been extremely challenging as its ATP …

The timing and duration of sleep results from the interaction between a homeostatic sleep–
wake-driven process and a periodic circadian process, and involves changes in gene …

Cyclin A1 is an alternative A-type cyclin that is essential for spermatogenesis, but it is also
expressed in hematopoietic progenitor cells and in acute myeloid leukemia. Its functions …

Next-generation sequencing technologies have recently been used in pharmacogenomic
studies to characterize large panels of cancer cell lines at the genomic and transcriptomic …

Problem Decidual macrophages (d M φ) of the mother and placental macrophages (H
ofbauer cells, HC) of the fetus are deployed at a critical location: the feto‐maternal interface …

Abnormal regulation of progression from G1 to S phase of the cell cycle by altered activity of
cyclin-dependent kinases (CDKs) is a hallmark of cancer. However, inhibition of CDKs …

ING5 belongs to the Inhibitor of Growth (ING) candidate tumor suppressor family, whose
functions have been involved in the regulation of chromatin remodeling, cell cycle …