During the early meiotic prophase, connections are established between chromosomes and
cytoplasmic motors via a nuclear envelope bridge, known as a LINC (linker of …

How eukaryotic cells control their duplication is a fascinating example of how a biological
system self-organizes specific activities to temporally order cellular events. During cell cycle …

Crossover formation is essential for proper segregation of homologous chromosomes during
meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) …

Accurate chromosome segregation during meiosis requires the establishment of at least one
crossover (CO) between each pair of homologous chromosomes. CO formation depends on …

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized
by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix …

Meiotic recombination is highly regulated to ensure precise segregation of homologous
chromosomes. Evidence from diverse organisms indicates that the synaptonemal complex …

Interactions between chromosomes and LINC (linker of nucleoskeleton and cytoskeleton)
complexes in the nuclear envelope (NE) promote homolog pairing and synapsis during …

MicroRNAs (miRNAs) are believed to play important roles in mammalian spermatogenesis
but the in vivo functions of single miRNAs in this highly complex developmental process …

Sex chromosome aneuploidies are among the most common variations in human whole
chromosome copy numbers, with an estimated prevalence in the general population of 1 …

During meiosis, each pair of homologous chromosomes becomes connected by at least one
crossover, as required for accurate segregation, and adjacent crossovers are widely …