Genome‐wide association studies for discovery of genes involved in asthma

L Akhabir, AJ Sandford - Respirology, 2011 - Wiley Online Library
Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

SNPs in sites for DNA methylation, transcription factor binding, and miRNA targets leading to allele-specific gene expression and contributing to complex disease risk …

M Vohra, AR Sharma, N Prabhu B, PS Rai - Public Health Genomics, 2021 - karger.com
Introduction: The complex genetic diversity among human populations results from an
assortment of factors acting at various sequential levels, including mutations, population …

Prenatal PM2. 5 exposure and vitamin D–associated early persistent atopic dermatitis via placental methylation

SI Yang, SH Lee, SY Lee, HC Kim, HB Kim… - Annals of Allergy …, 2020 - Elsevier
Background The effects of prenatal particulate matter with an aerodynamic diameter ranging
from 0.1 μm to 2.5 μm (PM 2.5) and vitamin D on atopic dermatitis (AD) phenotypes have not …

Nasal DNA methylation differentiates severe from non‐severe asthma in African‐American children

T Zhu, X Zhang, X Chen, AP Brown, MT Weirauch… - Allergy, 2021 - Wiley Online Library
Background Asthma is highly heterogeneous, and severity evaluation is key to asthma
management. DNA methylation (DNAm) contributes to asthma pathogenesis. This study …

Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population

F Li, L Jiang, SA Willis-Owen, Y Zhang, J Gao - BMC medical genetics, 2011 - Springer
Background Asthma is a genetically heterogeneous disease. Polymorphisms of genes
encoding components of the vitamin D pathway have been reported to associate with the …

Genetic mechanisms of asthma and the implications for drug repositioning

Y Huo, HY Zhang - Genes, 2018 - mdpi.com
Asthma is a chronic disease that is caused by airway inflammation. The main features of
asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The …

Asthma in children and adolescents: a comprehensive approach to diagnosis and management

C Chang - Clinical reviews in allergy & immunology, 2012 - Springer
Asthma is a chronic disease that has a significant impact on quality of life and is particularly
important in children and adolescents, in part due to the higher incidence of allergies in …

A genome-wide association study of total serum and mite-specific IgEs in asthma patients

JH Kim, HS Cheong, JS Park, AS Jang, ST Uh… - PLoS …, 2013 - journals.plos.org
Immunoglobulin E (IgE) is one of the central players in asthma and allergic diseases.
Although the serum IgE level, a useful endophenotype, is generally increased in patients …

Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?

S Weidinger, H Baurecht, A Naumann… - Current opinion in …, 2010 - journals.lww.com
Genome-wide association studies on IgE regulation: are genet... : Current Opinion in Allergy
and Clinical Immunology Genome-wide association studies on IgE regulation: are genetics of …

Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis

Z Bakoyan, Y Cao, SR Hansson… - Pediatric Allergy and …, 2024 - Wiley Online Library
Fetal programming may arise from prenatal exposure and increase the risk of diseases later
in life, potentially mediated by the placenta. The objective of this systematic review was to …