Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
Why nanoparticles prefer liver macrophage cell uptake in vivo
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery
As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …
chemotherapeutic drugs have shown considerable potential to reverse the …
Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy
Nanovesicles and bio-vesicles (BVs) have emerged as promising tools to achieve targeted
cancer therapy due to their ability to overcome many of the key challenges currently being …
cancer therapy due to their ability to overcome many of the key challenges currently being …
Nano delivery of chemotherapeutic ICD inducers for tumor immunotherapy
Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is
confirmed to activate the host immune system to prevent, control, and eliminate tumors …
confirmed to activate the host immune system to prevent, control, and eliminate tumors …
The progress and perspective of strategies to improve tumor penetration of nanomedicines
J Hu, X Yuan, F Wang, H Gao, X Liu, W Zhang - Chinese Chemical Letters, 2021 - Elsevier
Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many
researches are published to overcome the barriers that restrict tumor penetration and …
researches are published to overcome the barriers that restrict tumor penetration and …
Nano codelivery of oxaliplatin and folinic acid achieves synergistic chemo-immunotherapy with 5-fluorouracil for colorectal cancer and liver metastasis
FOLFOX, the combinational strategy of folinic acid (FnA), 5-fluorouracil (5-Fu), and
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis
L Sun, M Fan, D Huang, B Li, R Xu, F Gao, Y Chen - Biomaterials, 2021 - Elsevier
Pulmonary fibrosis is a rapidly progressive and fatal fibrotic lung disease with high mortality
and morbidity. However, pulmonary fibrosis therapy in the clinic has been limited by poor …
and morbidity. However, pulmonary fibrosis therapy in the clinic has been limited by poor …
Rationally designed polymer conjugate for tumor-specific amplification of oxidative stress and boosting antitumor immunity
The crosstalk between tumor and stroma cells is a central scenario in the tumor
microenvironment (TME). While the predominant effect of tumor cells on immune cells is …
microenvironment (TME). While the predominant effect of tumor cells on immune cells is …
Nanodelivery of cGAS-STING activators for tumor immunotherapy
Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …