Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Non-coding RNA in cancer drug resistance: underlying mechanisms and clinical applications

X Zhou, X Ao, Z Jia, Y Li, S Kuang, C Du… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a
serious, long-term threat to patients' health and life. Systemic chemotherapy remains the first …

Exosomal circRNAs in cancer: implications for therapy resistance and biomarkers

Z Lin, Y Ji, J Zhou, G Li, Y Wu, W Liu, Z Li, T Liu - Cancer Letters, 2023 - Elsevier
Despite the advances in cancer treatment in recent years, the development of resistance to
cancer therapy remains the biggest hurdle towards curative cancer treatments. Therefore …

Humanin and its pathophysiological roles in aging: A systematic review

D Coradduzza, A Congiargiu, Z Chen, S Cruciani… - Biology, 2023 - mdpi.com
Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

The role of lncRNA NEAT1 in human cancer chemoresistance

F Long, X Li, J Pan, H Ye, C Di, Y Huang, J Li… - Cancer Cell …, 2024 - Springer
Chemotherapy is currently one of the most effective methods in clinical cancer treatment.
However, chemotherapy resistance is an important reason for poor chemotherapy efficacy …

Enzymatically crosslinked magnetic starch-grafted poly (tannic acid) hydrogel for “smart” cancer treatment: an in vitro chemo/hyperthermia therapy study

M Eskandani, H Derakhshankhah, S Zare… - International journal of …, 2023 - Elsevier
A novel strategy was designed and developed based of horseradish peroxidase (HRP)-
mediated crosslinking of tyramine-functionalized starch (Tyr-St), tannic acid (TA) and …

Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress

MA Rahman, ASM Saikat, MS Rahman, M Islam… - Cells, 2023 - mdpi.com
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Proton sponge nanocomposites for synergistic tumor elimination via autophagy inhibition-promoted cell apoptosis and macrophage repolarization-enhanced immune …

Y Duan, W Zhang, Y Ouyang, Q Yang… - … Applied Materials & …, 2024 - ACS Publications
Cytoprotective autophagy and an immunosuppressive tumor microenvironment (TME) are
two positive promoters for tumor proliferation and metastasis that severely hinder therapeutic …

Mitochondrial signaling pathways and their role in cancer drug resistance

A Sharma, T Virmani, G Kumar, A Sharma, R Virmani… - Cellular …, 2024 - Elsevier
Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …

Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines

BP Rickard, M Overchuk, J Tulino, X Tan, FS Ligler… - Environmental …, 2023 - Springer
Background Exposure to per-and poly-fluoroalkyl substances (PFAS) has been associated
with significant alterations in female reproductive health. These include changes in …