Adaptive deep brain stimulation: From experimental evidence toward practical implementation
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
A systematic review of local field potential physiomarkers in Parkinson's disease: from clinical correlations to adaptive deep brain stimulation algorithms
Deep brain stimulation (DBS) treatment has proven effective in suppressing symptoms of
rigidity, bradykinesia, and tremor in Parkinson's disease. Still, patients may suffer from …
rigidity, bradykinesia, and tremor in Parkinson's disease. Still, patients may suffer from …
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease
This study compares the effects on motor symptoms between conventional deep brain
stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with …
stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with …
Subthalamic beta band suppression reflects effective neuromodulation in chronic recordings
LK Feldmann, WJ Neumann, P Krause… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Biomarkers for future adaptive deep brain stimulation still need
evaluation in clinical routine. Here, we aimed to assess stimulation‐induced modulation of …
evaluation in clinical routine. Here, we aimed to assess stimulation‐induced modulation of …
Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based
neurostimulation, with the potential of clinical implementation with the sensing-enabled …
neurostimulation, with the potential of clinical implementation with the sensing-enabled …
[HTML][HTML] Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease
Deep brain stimulation is a widely used therapy for Parkinson's disease (PD) but currently
lacks dynamic responsiveness to changing clinical and neural states. Feedback control has …
lacks dynamic responsiveness to changing clinical and neural states. Feedback control has …
Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease
Exaggerated local field potential bursts of activity at frequencies in the low beta band are a
well-established phenomenon in the subthalamic nucleus of patients with Parkinson's …
well-established phenomenon in the subthalamic nucleus of patients with Parkinson's …
[HTML][HTML] Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation
Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …