The ongoing outbreak of COVID-19 has quickly become a daunting challenge to global
health. In the absence of targeted therapy and a reported 5.5% case fatality rate in the …

A central paradigm of cardiovascular homeostasis is that impaired nitric oxide (NO)
bioavailability results in a wide array of cardiovascular dysfunction including incompetent …

Perioperative organ injury remains a medical, social and economic problem in cardiac
surgery. Patients with postoperative organ dysfunction have increases in morbidity, length of …

Ischemia reperfusion (IR)-induced oxidative stress, accompanied by inflammatory
responses, contributes to morbidity and mortality in numerous diseases such as acute …

Ischemia-reperfusion injury (IRI) is a process in which damage is induced in hypoxic tissue
when oxygen supply is resumed after ischemia. During IRI, restoration of reduced nitric …

Cardiovascular diseases (CVDs) represent a major concern for human health worldwide.
Emergencies in this field include wide repertories of studies dealing primarily with CVD …

Post-translational modifications based on redox reactions “switch on-off” the biological
activity of different downstream targets, modifying a myriad of processes and providing an …

Cisplatin is a promising therapeutic for the treatment of non-small cell lung cancer (NSCLC).
Unfortunately, a significant portion of NSCLC patients relapse due to cisplatin …

Amelioration of immune overactivity during sepsis is key to restoring hemodynamics,
microvascular blood flow, and tissue oxygenation, and in preventing multi-organ dysfunction …

The production dysregulation of reactive oxygen species (ROS) and nitric oxide (NO) in
ischemic tissues results in endothelial dysfunction, hyperinflammation and poor blood …