Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …

Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in
healthy individuals without diabetes. However, the metabolic response of a non-diabetic …

Obesity and its related metabolic disorders, such as diabetes and cardiovascular disease,
are major risk factors for morbidity and mortality in the world population. In this context …

Background Animal models are indispensable to understand the lipid metabolism and lipid
metabolic diseases. Over the last decade, the nematode Caenorhabditis elegans has …

The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms
to tightly couple fuel supply with energy demand across a wide range of physiologic and …

The comparatively simple Caenorhabditis elegans intestine fulfills many of the complex
functions of the mammalian digestive tract, liver, and fat tissues, while also having roles in …

Nutrient handling by higher organisms is a complex process that is regulated at the
transcriptional level. Studies over the past 15 years have highlighted the critical importance …

Total number born (TNB), number of stillborn (NSB), and gestation length (GL) are
economically important traits in pig production, and disentangling the molecular …

Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark
of aging. However, the physiologic and molecular regulation of autophagy in long-lived …