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Museum of spatial transcriptomics
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …
tumors, depends on the spatial organization of their cells. In the past decade, high …
Global positioning system: understanding long noncoding RNAs through subcellular localization
J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …
determinant of their molecular functions. LncRNAs are often thought of as chromatin …
Construction of a 3D whole organism spatial atlas by joint modelling of multiple slices with deep neural networks
Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …
architecture of tissues. Currently, ST data analysis is often restricted to a single two …
High-resolution 3D spatiotemporal transcriptomic maps of develo** Drosophila embryos and larvae
M Wang, Q Hu, T Lv, Y Wang, Q Lan, R **ang, Z Tu… - Developmental Cell, 2022 - cell.com
Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …
gene expression patterns are critical for the understanding of complex pathways and …
Ultrasensitive proteome analysis using paramagnetic bead technology
In order to obtain a systems‐level understanding of a complex biological system, detailed
proteome information is essential. Despite great progress in proteomics technologies …
proteome information is essential. Despite great progress in proteomics technologies …
The Drosophila embryo at single-cell transcriptome resolution
By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …
Transcriptional enhancers: from properties to genome-wide predictions
Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …
expression. These are established by the coordinated action of genomic regulatory …
The cis-regulatory dynamics of embryonic development at single-cell resolution
Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …
is a long-standing challenge. Recent advances in measuring gene expression in single cells …
The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals
Bgee is a database to retrieve and compare gene expression patterns in multiple animal
species, produced by integrating multiple data types (RNA-Seq, Affymetrix, in situ …
species, produced by integrating multiple data types (RNA-Seq, Affymetrix, in situ …
Uberon, an integrative multi-species anatomy ontology
We present Uberon, an integrated cross-species ontology consisting of over 6,500 classes
representing a variety of anatomical entities, organized according to traditional anatomical …
representing a variety of anatomical entities, organized according to traditional anatomical …