Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

Construction of a 3D whole organism spatial atlas by joint modelling of multiple slices with deep neural networks

G Wang, J Zhao, Y Yan, Y Wang, AR Wu… - Nature Machine …, 2023 - nature.com
Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …

High-resolution 3D spatiotemporal transcriptomic maps of develo** Drosophila embryos and larvae

M Wang, Q Hu, T Lv, Y Wang, Q Lan, R **ang, Z Tu… - Developmental Cell, 2022 - cell.com
Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

Ultrasensitive proteome analysis using paramagnetic bead technology

CS Hughes, S Foehr, DA Garfield… - Molecular systems …, 2014 - embopress.org
In order to obtain a systems‐level understanding of a complex biological system, detailed
proteome information is essential. Despite great progress in proteomics technologies …

The Drosophila embryo at single-cell transcriptome resolution

N Karaiskos, P Wahle, J Alles, A Boltengagen, S Ayoub… - Science, 2017 - science.org
By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Transcriptional enhancers: from properties to genome-wide predictions

D Shlyueva, G Stampfel, A Stark - Nature Reviews Genetics, 2014 - nature.com
Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

The cis-regulatory dynamics of embryonic development at single-cell resolution

DA Cusanovich, JP Reddington, DA Garfield, RM Daza… - Nature, 2018 - nature.com
Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals

FB Bastian, J Roux, A Niknejad, A Comte… - Nucleic acids …, 2021 - academic.oup.com
Bgee is a database to retrieve and compare gene expression patterns in multiple animal
species, produced by integrating multiple data types (RNA-Seq, Affymetrix, in situ …

Uberon, an integrative multi-species anatomy ontology

CJ Mungall, C Torniai, GV Gkoutos, SE Lewis… - Genome biology, 2012 - Springer
We present Uberon, an integrated cross-species ontology consisting of over 6,500 classes
representing a variety of anatomical entities, organized according to traditional anatomical …