Candida albicans Biofilms and Human Disease

CJ Nobile, AD Johnson - Annual review of microbiology, 2015 - annualreviews.org
In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …

Development and regulation of single- and multi-species Candida albicans biofilms

MB Lohse, M Gulati, AD Johnson… - Nature Reviews …, 2018 - nature.com
Candida albicans is among the most prevalent fungal species of the human microbiota and
asymptomatically colonizes healthy individuals. However, it is also an opportunistic …

Transcriptomics technologies

R Lowe, N Shirley, M Bleackley, S Dolan… - PLoS computational …, 2017 - journals.plos.org
Transcriptomics technologies are the techniques used to study an organism's transcriptome,
the sum of all of its RNA transcripts. The information content of an organism is recorded in …

Candida albicans biofilms and polymicrobial interactions

NO Ponde, L Lortal, G Ramage, JR Naglik… - Critical reviews in …, 2021 - Taylor & Francis
Candida albicans is a common fungus of the human microbiota. While generally a harmless
commensal in healthy individuals, several factors can lead to its overgrowth and cause a …

A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing

CG Pierce, P Uppuluri, AR Tristan, FL Wormley Jr… - Nature protocols, 2008 - nature.com
The incidence of fungal infections has increased significantly over the past decades. Very
often these infections are associated with biofilm formation on implanted biomaterials and/or …

Multidrug tolerance of biofilms and persister cells

K Lewis - Bacterial biofilms, 2008 - Springer
Bacterial populations produce a small number of dormant persister cells that exhibit
multidrug tolerance. All resistance mechanisms do essentially the same thing: prevent the …

Genetic control of Candida albicans biofilm development

JS Finkel, AP Mitchell - Nature Reviews Microbiology, 2011 - nature.com
Candida species cause frequent infections owing to their ability to form biofilms—surface-
associated microbial communities—primarily on implanted medical devices. Increasingly …

Candida Biofilms: an Update

G Ramage, SP Saville, DP Thomas… - Eukaryotic cell, 2005 - Am Soc Microbiol
Our classical perception of microorganisms as unicellular life forms is almost entirely based
on the pure-culture mode of growth; since microbial suspensions can be diluted to a single …

Fungal biofilm resistance

G Ramage, R Rajendran, L Sherry… - International journal of …, 2012 - Wiley Online Library
Fungal biofilm infections have become increasingly recognised as a significant clinical
problem. One of the major reasons behind this is the impact that these have upon treatment …

The developmental model of microbial biofilms: ten years of a paradigm up for review

RD Monds, GA O'Toole - Trends in microbiology, 2009 - cell.com
For the past ten years, the developmental model of microbial biofilm formation has served as
the major conceptual framework for biofilm research; however, the paradigmatic value of this …