Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

Background Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which
concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by …

Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …

Human height is a representative phenotype to elucidate genetic architecture. However, the
majority of large studies have been performed in European population. To investigate the …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …