Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility
Earlier we created a chemical hazard database via natural language processing of dossiers
submitted to the European Chemical Agency with approximately 10 000 chemicals. We …
submitted to the European Chemical Agency with approximately 10 000 chemicals. We …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
Docking techniques in pharmacology: How much promising?
Docking techniques in pharmacology: How much promising? - ScienceDirect Skip to main
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Systems toxicology: from basic research to risk assessment
Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …
large networks of molecular and functional changes occurring across multiple levels of …
Animal testing and its alternatives–The most important omics is economics
For a long time, the discussion about animal testing vs its alternatives centered on animal
welfare. This was a static warfare, or at least a gridlock, where life scientists had to take a …
welfare. This was a static warfare, or at least a gridlock, where life scientists had to take a …
A framework for chemical safety assessment incorporating new approach methodologies within REACH
N Ball, R Bars, PA Botham, A Cuciureanu… - Archives of …, 2022 - Springer
The long-term investment in new approach methodologies (NAMs) within the EU and other
parts of the world is beginning to result in an emerging consensus of how to use information …
parts of the world is beginning to result in an emerging consensus of how to use information …
[HTML][HTML] Probabilistic risk assessment–the keystone for the future of toxicology
Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
The relevance and potential roles of microphysiological systems in biology and medicine
JP Wikswo - Experimental biology and medicine, 2014 - journals.sagepub.com
Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …