The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …
energy production. Several studies have found a relationship between mitochondrial …
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
The ability of stem cells to propagate indefinitely is believed to occur via the fine modulation
of pathways commonly involved in cellular senescence, including the telomerase, the p53 …
of pathways commonly involved in cellular senescence, including the telomerase, the p53 …
Mitochondrial dysfunction in depression
Y Bansal, A Kuhad - Current neuropharmacology, 2016 - ingentaconnect.com
Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …
impact on socio-occupational and well being of individual. The exact pathophysiology of …
Mitochondria and the dynamic control of stem cell homeostasis
The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …
changes. This process is particularly critical for stem cells, which need to preserve their …
HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2
Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …
anabolic requirements, thus potentially inducing cancer-like metabolic transformation …
OXPHOS mutations and neurodegeneration
Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
Abstract α-Synuclein becomes misfolded and aggregated upon damage by various factors,
for example, by reactive oxygen species. These aggregated forms have been proposed to …
for example, by reactive oxygen species. These aggregated forms have been proposed to …
Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications
Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
Interleukin-1 and acute brain injury
KN Murray, AR Parry-Jones, SM Allan - Frontiers in cellular …, 2015 - frontiersin.org
Inflammation is the key host-defense response to infection and injury, yet also a major
contributor to a diverse range of diseases, both peripheral and central in origin. Brain injury …
contributor to a diverse range of diseases, both peripheral and central in origin. Brain injury …