Sleep disturbance is the most prominent symptom in depressive patients and was formerly
regarded as a main secondary manifestation of depression. However, many longitudinal …

Wearable and implantable active medical devices (WIMDs) are transformative solutions for
improving healthcare, offering continuous health monitoring, early disease detection …

Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging
technique that enables in vivo reconstruction of the brain's white matter connections at …

Depression is associated with social risk factors, social impairments and poor social
functioning. This paper gives an overview of these social aspects using the NIMH Research …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Target identification and contact selection are known contributors to variability in efficacy
across different clinical indications of deep brain stimulation surgery. A retrospective …

The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Brain–machine interfaces (BMIs) create closed-loop control systems that interact with the
brain by recording and modulating neural activity and aim to restore lost function, most …