Structural and biochemical alterations in dendritic spines as key mechanisms for severe mental illnesses
S Reyes-Lizaola, U Luna-Zarate… - Progress in Neuro …, 2024 - Elsevier
Severe mental illnesses (SMI) collectively affect approximately 20% of the global population,
as estimated by the World Health Organization (WHO). Despite having diverse etiologies …
as estimated by the World Health Organization (WHO). Despite having diverse etiologies …
Autism spectrum disorder and various mechanisms behind it
P Rajabi, AS Noori, J Sargolzaei - Pharmacology Biochemistry and …, 2024 - Elsevier
Abstract Autism Spectrum Disorder (ASD) is a complex and heterogeneous
neurodevelopmental condition characterized by a range of social, communicative, and …
neurodevelopmental condition characterized by a range of social, communicative, and …
Key roles of CACNA1C/Cav1. 2 and CALB1/calbindin in prefrontal neurons altered in cognitive disorders
Importance The risk of mental disorders is consistently associated with variants inCACNA1C
(L-type calcium channel Cav1. 2) but it is not known why these channels are critical to …
(L-type calcium channel Cav1. 2) but it is not known why these channels are critical to …
[HTML][HTML] Functional evaluation of a novel GRIN2B missense variant associated with epilepsy and intellectual disability
X Wang, D Mei, L Gou, S Zhao, C Gao, J Guo, S Luo… - Neuroscience, 2023 - Elsevier
Epilepsy, a neurological condition, is widely prevalent among individuals with intellectual
disability (ID). It is well established that N-methyl-D-aspartate (NMDA) receptors play an …
disability (ID). It is well established that N-methyl-D-aspartate (NMDA) receptors play an …
[HTML][HTML] Decoding the genetic landscape of autism: A comprehensive review
BACKGROUND Autism spectrum disorder (ASD) is a complex neurodevelopmental
condition characterized by heterogeneous symptoms and genetic underpinnings. Recent …
condition characterized by heterogeneous symptoms and genetic underpinnings. Recent …
Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition …
JM Wierońska, P Cieślik, G Burnat, L Kalinowski - Biomolecules, 2023 - mdpi.com
The Morris water maze (MWM) is regarded as one of the most popular tests for detecting
spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among …
spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among …
Metabolic characterization of neurogenetic disorders involving glutamatergic neurotransmission
S Illescas, Y Diaz‐Osorio, A Serradell… - Journal of Inherited …, 2024 - Wiley Online Library
The study of inborn errors of neurotransmission has been mostly focused on monoamine
disorders, GABAergic and glycinergic defects. The study of the glutamatergic synapse using …
disorders, GABAergic and glycinergic defects. The study of the glutamatergic synapse using …
[HTML][HTML] Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology
M Korinek, MC Serra, FESA Rahman… - Physiological …, 2024 - pmc.ncbi.nlm.nih.gov
N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors
critical for synaptic transmission and plasticity, and for the development of neural circuits …
critical for synaptic transmission and plasticity, and for the development of neural circuits …
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice
Sensory abnormalities are observed in~ 90% of individuals with autism spectrum disorders
(ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor …
(ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor …
Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and Is Associated with Correction of AMPA Receptor-Mediated Synaptic Dysfunction
R Jada, V Borisov, E Laury, S Halpert, NS Levy… - International Journal of …, 2023 - mdpi.com
Purposeful induction of fever for healing, including the treatment of epilepsy, was used over
2000 years ago by Hippocrates. More recently, fever has been demonstrated to rescue …
2000 years ago by Hippocrates. More recently, fever has been demonstrated to rescue …