Structural and functional aspects of Ebola virus proteins
Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …
How glutamate is managed by the blood–brain barrier
RA Hawkins, JR Viña - Biology, 2016 - mdpi.com
A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
Protein interaction map** identifies RBBP6 as a negative regulator of Ebola virus replication
Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about
how EBOV usurps host pathways during infection. To address this, we used affinity tag …
how EBOV usurps host pathways during infection. To address this, we used affinity tag …
Hippo signaling pathway regulates Ebola virus transcription and egress
J Liang, MA Djurkovic, CG Leavitt, O Shtanko… - Nature …, 2024 - nature.com
Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we
identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical …
identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical …
[HTML][HTML] The Ebola virus nucleoprotein recruits the host PP2A-B56 phosphatase to activate transcriptional support activity of VP30
Transcription of the Ebola virus genome depends on the viral transcription factor VP30 in its
unphosphorylated form, but the underlying molecular mechanism of VP30 …
unphosphorylated form, but the underlying molecular mechanism of VP30 …
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection
Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly
correlative with fatalities. However, the mechanisms leading to T-cell depletion remain …
correlative with fatalities. However, the mechanisms leading to T-cell depletion remain …
Ebola VP40 in exosomes can cause immune cell dysfunction
ML Pleet, A Mathiesen, C DeMarino… - Frontiers in …, 2016 - frontiersin.org
Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of
causing severe hemorrhagic fever with up to 80–90% mortality rates. The most recent …
causing severe hemorrhagic fever with up to 80–90% mortality rates. The most recent …
[HTML][HTML] RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription
CA Richard, V Rincheval, S Lassoued, J Fix… - PLoS …, 2018 - journals.plos.org
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs)
in which all the components of the viral RNA polymerase are concentrated. In this work, we …
in which all the components of the viral RNA polymerase are concentrated. In this work, we …
Distinct genome replication and transcription strategies within the growing filovirus family
Research on filoviruses has historically focused on the highly pathogenic ebola-and
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …
Evidence for viral mRNA export from Ebola virus inclusion bodies by the nuclear RNA export factor NXF1
L Wendt, J Brandt, DS Ushakov, BS Bodmer… - Journal of …, 2022 - Am Soc Microbiol
Many negative-sense RNA viruses, including the highly pathogenic Ebola virus (EBOV), use
cytoplasmic inclusion bodies (IBs) for viral RNA synthesis. However, it remains unclear how …
cytoplasmic inclusion bodies (IBs) for viral RNA synthesis. However, it remains unclear how …