Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Both aging and cancer are characterized by a series of partially overlap**" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …