Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

The ability to reproduce early stages of human neurodevelopment in the laboratory is one of
the most exciting fields in modern neuroscience. The inaccessibility of the healthy human …

The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

Brain organoids are three-dimensional, tissue-engineered neural models derived from
induced pluripotent stem cells that enable studies of neurodevelopmental and disease …

Brain organoids have rapidly become established as promising tools for studying both the
normal embryonic development of the brain and the mechanistic roots of …

We propose that the teratoma, a recognized standard for validating pluripotency in stem
cells, could be a promising platform for studying human developmental processes …

The development of therapeutic interventions for hearing loss requires fundamental
knowledge about the signaling pathways controlling tissue development as well as the …

The human brain is characterized by an extraordinary complexity of neuronal and
nonneuronal cell types, wired together into patterned neuronal circuits, which represent the …

Epilepsy is a common neurological disorder characterized by recurrent and unprovoked
seizures due to neuronal hyperactivity. A large proportion of epilepsy cases begin during …

Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual
mental, behavioral, and emotional patterns leading to suffering and disability. These …