Progress and problems with the use of suicide genes for targeted cancer therapy
Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility
This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily
Insight regarding how diverse enzymatic functions and reactions have evolved from
ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and …
ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and …
Revealing unexplored sequence-function space using sequence similarity networks
The rapidly expanding number of protein sequences found in public databases can improve
our understanding of how protein functions evolve. However, our current knowledge of …
our understanding of how protein functions evolve. However, our current knowledge of …
Enzyme/prodrug systems for cancer gene therapy
The use of enzyme/prodrug system has gained attention because it could help improve the
efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells …
efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells …
Azoreductases in drug metabolism
A Ryan - British Journal of Pharmacology, 2017 - Wiley Online Library
Azoreductases are flavoenzymes that have been characterized in a range of prokaryotes
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy
Gene-directed enzyme-prodrug therapy (GDEPT) is a promising anti-cancer strategy.
However, inadequate prodrugs, inefficient prodrug activation, and a lack of non-invasive …
However, inadequate prodrugs, inefficient prodrug activation, and a lack of non-invasive …
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation
Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells
to prodrugs such as metronidazole (MTZ), enabling selective cell-ablation paradigms that …
to prodrugs such as metronidazole (MTZ), enabling selective cell-ablation paradigms that …
Escherichia coli NemA Is an Efficient Chromate Reductase That Can Be Biologically Immobilized to Provide a Cell Free System for Remediation of Hexavalent …
Hexavalent chromium is a serious and widespread environmental pollutant. Although many
bacteria have been identified that can transform highly water-soluble and toxic Cr (VI) to …
bacteria have been identified that can transform highly water-soluble and toxic Cr (VI) to …
Single-and two-electron reduction of nitroaromatic compounds by flavoenzymes: Mechanisms and implications for cytotoxicity
N Čėnas, A Nemeikaitė-Čėnienė… - International journal of …, 2021 - mdpi.com
Nitroaromatic compounds (ArNO2) maintain their importance in relation to industrial
processes, environmental pollution, and pharmaceutical application. The manifestation of …
processes, environmental pollution, and pharmaceutical application. The manifestation of …