Abstract Purpose of Review This review examines lifestyle modification for obesity
management with the goal of identifying treatment components that could support the use of …

Importance Approximately 9% of US adults experience major depression each year, with a
lifetime prevalence of approximately 17% for men and 30% for women. Observations Major …

Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core
symptoms and no medications approved by the US Food and Drug Administration. Novel …

Importance Alzheimer disease (AD), a neurodegenerative disease characterized by β-
amyloid plaques and τ tangles in the brain, represents an unmet medical need with no fully …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

OBJECTIVES: Elevated rates of mental health concerns have been identified during the
coronavirus disease 2019 (COVID-19) pandemic. In this study, we sought to evaluate …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

Objective: New antidepressant treatments are needed that are effective, rapid acting, safe,
and tolerable. Intermittent theta-burst stimulation (iTBS) is a noninvasive brain stimulation …

Importance Bipolar II disorder (BDII) is a debilitating condition frequently associated with
difficult-to-treat depressive episodes. Psilocybin has evidence for rapid-acting …

Suicidal ideations (SI), often called suicidal thoughts or ideas, is a broad term used to
describe a range of contemplations, wishes, and preoccupations with death and suicide …