Helicobacter pylori are spiral-shaped gram-negative bacteria with polar flagella that live
near the surface of the human gastric mucosa. They have evolved intricate mechanisms to …

Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen A
(cagA) gene is associated with gastric carcinoma. Recent studies have shed light on the …

Integrins are important mammalian receptors involved in normal cellular functions as well as
pathogenesis of chronic inflammation and cancer. We propose that integrins are exploited …

Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA+ H. pylori strains
are more virulent than cagA− strains and are associated with gastric carcinoma. The cagA …

The Helicobacter pylori immunodominant protein, CagA, is associated with severe gastritis
and carcinoma. Injection of CagA into gastric epithelial cells by type IV secretion leads to …

The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the
bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes …

CagA delivered from Helicobacter pylori into gastric epithelial cells undergoes tyrosine
phosphorylation and induces host cell morphological changes. Here we show that CagA …

Many bacterial pathogens inject into host cells effector proteins that are substrates for host
tyrosine kinases such as Src and Abl family kinases. Phosphorylated effectors eventually …

Helicobacter pylori infection is the major risk factor for gastric adenocarcinoma. The link with
gastric adenocarcinoma is partly due to the H. pylori CagA oncoprotein. CagA is responsible …

Helicobacter pylori is a highly successful human‐specific gastric pathogen that colonizes
more than half the world's population. Infection with this bacterium can induce gastric …