Summary In 1969, HH Jasper, AA Ward, and A. Pope and the Public Health Service
Advisory Committee on the Epilepsies of the National Institutes of Health (NIH) published the …

Simple Summary Magnesium is an essential nutrient, also called an essential mineral or
element. Magnesium is vastly important in all life, with vital roles for the healthy functioning …

Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Brain-state transitions are readily apparent from changes in brain rhythms, but are difficult to
predict, suggestive that the underlying cause is latent to passive recording methods. Among …

Single-unit recordings performed in temporal lobe epilepsy patients and in models of
temporal lobe seizures have shown that interneurons are active at focal seizure onset. We …

Seizure liability remains a significant cause of attrition throughout drug development.
Advances in stem cell biology coupled with an increased understanding of the role of ion …

Human and animal EEG data demonstrate that focal seizures start with low-voltage fast
activity, evolve into rhythmic burst discharges and are followed by a period of suppressed …

Investigations into seizure initiation, in recent years, have focused almost entirely upon
alterations of interneuronal function, chloride homeostasis, and extracellular potassium …

Analyzing neuronal activity during human seizures is pivotal to understanding mechanisms
of seizure onset and propagation. These analyses, however, invariably using extracellular …

Introduction The increasing incidence of mental illnesses and neurodegenerative diseases
results in a high demand for drugs targeting the central nervous system (CNS). These drugs …