The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

▪ Abstract Protein splicing is a form of posttranslational processing that consists of the
excision of an intervening polypeptide sequence, the intein, from a protein, accompanied by …

Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic
microorganisms. Since the structure of pantothenic acid was determined, many analogues of …

Pantothenate is vitamin B5 and is the key precursor for the biosynthesis of coenzyme A
(CoA), a universal and essential cofactor involved in a myriad of metabolic reactions …

Coenzyme A (I) and enzyme-bound phosphopantetheine (II) function as acyl carriers and as
carbonyl activating groups for Claisen reactions as well as for amide-, ester-, and thioester …

MUC1, a glycoprotein overexpressed by a variety of human adenocarcinomas, is a type I
transmembrane protein (MUC1/TM) that soon after its synthesis undergoes proteolytic …

Covering: 1933–2004Pantothenate is an essential metabolite for all biological systems,
however the biosynthetic pathway is limited to plants, eubacteria and archaea. This …

This review examines the mechanisms propelling cofactor-independent, organic cofactor-
dependent and metal-dependent decarboxylase chemistry. Decarboxylation, the removal of …

The Corynebacterium glutamicum panD gene was identified by functional complementation
of an Escherichia coli panD mutant strain. Sequence analysis revealed that the coding …

Previously, we showed that a major in vitro and in vivo mechanism of resistance to
pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug …