The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

We introduce a direct conversion of alkyl thiols into boronic acids, facilitated by a water-
soluble phosphine, 1, 3, 5-triaza-7-phosphaadamantane (PTA), in conjunction with …

Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …

Synthetic strategies to assemble peptide fragments are in high demand to access
homogeneous proteins for various applications. Here, we combined native chemical ligation …

Native chemical ligation combined with desulfurization has become a powerful strategy for
the chemical synthesis of proteins. Here we describe the use of a new thiol additive, methyl …

Despite the unique chemical properties of selenocysteine (Sec), ligation at Sec is an under‐
utilized methodology for protein synthesis. We describe herein an unprecedented protocol …

Visible-light-induced specific desulfurization of cysteinyl peptides has been explored. The
photocatalytic desulfurization catalyzed by Ru (bpy) 32+ can proceed efficiently at room …

Prolyl thioesters have shown significantly lower reactivities in native chemical ligation (NCL)
in comparison to that of the alanyl thioester. This report describes a mild and efficient …

The synthesis of suitably protected β-selenophenylalanine and β-selenoleucine amino acids
was accomplished from Garner's aldehyde as a common starting point. These selenoamino …