T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that
mounts strong responses to foreign antigens but is largely unresponsive to self–antigens …

Differentiation of early thymocytes into mature T cells depends upon intrathymic T cell
contact with major histocompatibility complex (MHC) molecules, ie, H-2 molecules in mice. T …

Metazoan organisms may discriminate between self and non-self not only by the presence
of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive …

The use of allogeneic bone marrow transplantation as a means of inducing donor-specific
tolerance across MHC barriers could provide an immunologically specific conditioning …

Clinical organ transplantation between genetically disparate individuals currently requires
the use of chemotherapeutic agents to suppress the rejection reaction. The deleterious side …

Mixed allogeneically reconstituted mice (B10+ B10. D2----B10) that specifically accept B10.
D2 tail skin allografts were examined for in vivo and in vitro immunocompetence, patterns of …

Transgenic mice expressing a T cell receptor hetemdimer specific for a fragment of pigeon
cytochrome c plus an MHC class II molecule (IE”) have been made. We find that H-2k afi …

Bone marrow transplantation (BMT) has considerable potential for the treatment of
malignancies, hemoglobinopathies, and autoimmune diseases, as well as the induction of …

The thymus has two important roles in controlling the specificity of T lymphocytes. First, T
cells differentiating in the thymus are rendered tolerant of 'self'antigens, particularly antigens …

▪ Abstract Achieving transplanatation tolerance is an important goal in the effort to reduce
long-term morbidity and mortality in organ transplant recipients. Robust, lifelong, donor …