Eyeing up the future of the pupillary light reflex in neurodiagnostics

CA Hall, RP Chilcott - Diagnostics, 2018 - mdpi.com
The pupillary light reflex (PLR) describes the constriction and subsequent dilation of the
pupil in response to light as a result of the antagonistic actions of the iris sphincter and …

Innovative diagnostic tools for early detection of Alzheimer's disease

C Laske, HR Sohrabi, SM Frost, K López-de-Ipiña… - Alzheimer's & …, 2015 - Elsevier
Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive
(cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

The eye as a biomarker for Alzheimer's disease

JKH Lim, QX Li, Z He, AJ Vingrys, VHY Wong… - Frontiers in …, 2016 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia
and eventual death. It is the leading cause of dementia and the number of cases are …

Light-induced pupillary responses in Alzheimer's disease

PS Chougule, RP Najjar, MT Finkelstein… - Frontiers in …, 2019 - frontiersin.org
The impact of Alzheimer's disease (AD) on the pupillary light response (PLR) is
controversial, being dependent on the stage of the disease and on the experimental …

Untreated poor vision: a contributing factor to late-life dementia

MAM Rogers, KM Langa - American journal of epidemiology, 2010 - academic.oup.com
Ophthalmologic abnormalities have been described in patients with dementia, but the extent
to which poor vision and treatment for visual disorders affect cognitive decline is not well …

Alzheimer's disease and retinal neurodegeneration

L Guo, J Duggan, MF Cordeiro - Current Alzheimer Research, 2010 - ingentaconnect.com
Alzheimer's disease (AD) is the major cause of dementia in the world. Although the
entorhinal cortex and hippocampal complex are best known as the sites of early pathology …

Cholinergic deficiency in Alzheimer's and Parkinson's disease: evaluation with pupillometry

DF Fotiou, V Stergiou, D Tsiptsios, C Lithari… - International Journal of …, 2009 - Elsevier
The aim of the study was to evaluate the cholinergic deficiency in Alzheimer's (AD) and
Parkinson's disease (PD). For this purpose, pupil size changes and mobility were assessed …

Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease

MK Ikram, CY Cheung, TY Wong… - Journal of Neurology …, 2012 - jnnp.bmj.com
Alzheimer's disease (AD) is the most common cause of dementia. Furthermore, over the last
few decades, there has been a shift towards identifying earlier stages of AD, which include …

Eye tracking–The overlooked method to measure cognition in neurodegeneration?

APA Bueno, JR Sato, M Hornberger - Neuropsychologia, 2019 - Elsevier
Eye tracking (ET) studies are becoming increasingly popular due to rapid methodological
and technological advances as well as the development of cost efficient and portable eye …