A key part of the development of metal based Positron Emission Tomography probes is the
chelation of the radiometal. In this review the recent developments in the chelation of four …

Chelators are necessary in nuclear medicine imaging to direct an inorganic radionuclide, a
radiometal, to a desired target; unfortunately, there is no 'one-size-fits-all'chelator. As the …

Very rigid tetra-, penta-, hexa-, hepta-and octadentate bispidine ligands are well
preorganized for specific coordination geometries. The broad range of coordination …

Thediazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a
naturally occurring scaffold with interesting features. Bispidine can form different conformers …

Several limitations of 18F and other non-metallic isotopes have been emphasized by the
development of macromolecular biotargeting agents for cancer, including peptides …

Several bifunctional chelators have been synthesized in the last years for the development
of new 64 Cu-based PET agents for in vivo imaging. When designing a metal-based PET …

Radiolabeled antibodies are powerful tools for both imaging and therapy in the field of
nuclear medicine. Radiolabeling methods that do not release radionuclides from parent …

Bifunctional chelators as parts of modular metal‐based radiopharmaceuticals are
responsible for stable complexation of the radiometal ion and for covalent linkage between …

The efficient transformation of the hexadentate bispidinol 1 into carbamate derivatives yields
functional bispidines enabling convenient functionalization for targeted imaging. The …

The synthesis and CuII, NiII, ZnII, CoII, and GaIII coordination chemistry of the two isomeric
hexadentate N5O ligands 6-[[9-hydroxy-1, 5-bis (methoxycarbonyl)-7-methyl-6, 8-bis (pyridin …