Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

Allergic diseases are the most common chronic immune‐mediated disorders and can
manifest with an enormous diversity in clinical severity and symptoms. Underlying …

Background The induction of allergen-specific IgE-blocking antibodies is a hallmark of
allergen immunotherapy (AIT). The inhibitory bioactivity has largely been attributed to IgG 4; …

Background Pollen exposure induces local and systemic allergic immune responses in
sensitized individuals, but nonsensitized individuals also are exposed to pollen. The kinetics …

Objective Allergen immunotherapy (AIT) is the therapeutic exposure to an allergen or
allergens selected by clinical assessment and allergy testing to decrease allergic symptoms …

Highlights•Allergen immunotherapy mainly induces T regulatory cells and blocking IgG4
antibodies.•Tolerance induction and asthma prevention are key goals of …

Background Subcutaneous venom immunotherapy (VIT) represents an effective treatment
against bee venom allergy. However, it involves long treatment times, high costs, and the …

Sublingual immunotherapy (SLIT) is used worldwide to treat house dust mites (HDM)
allergy. Epitope specific immunotherapy with peptide vaccines is used far less, but it is of …

Background: Solubility is a common feature of allergens. However, the causative
relationship between this protein-intrinsic feature and sensitization capacity of allergens is …

Mediator release assays analyze in vitro immunoglobulin E (IgE)-mediated degranulation
and secretion of mediators by effector cells, such as mast cells and basophils, upon …