Structural mechanisms of CFTR function and dysfunction
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
critical role in regulating transepithelial movement of water and electrolyte in exocrine …
CFTR structure and cystic fibrosis
N Cant, N Pollock, RC Ford - The international journal of biochemistry & …, 2014 - Elsevier
CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-
binding cassette family of membrane proteins. Although almost all members of this family …
binding cassette family of membrane proteins. Although almost all members of this family …
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra-and intermolecular interactions
Z Bozoky, M Krzeminski… - Proceedings of the …, 2013 - National Acad Sciences
Intrinsically disordered proteins play crucial roles in regulatory processes and often function
as protein interaction hubs. Here, we present a detailed characterization of a full-length …
as protein interaction hubs. Here, we present a detailed characterization of a full-length …
Molecular models of the open and closed states of the whole human CFTR protein
JP Mornon, P Lehn, I Callebaut - Cellular and Molecular Life Sciences, 2009 - Springer
Cystic fibrosis transmembrane conductance regulator (CFTR), involved in cystic fibrosis
(CF), is a chloride channel belonging to the ATP-binding cassette (ABC) superfamily. Using …
(CF), is a chloride channel belonging to the ATP-binding cassette (ABC) superfamily. Using …
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain
The Ca 2+ release-activated Ca 2+ channel is a principal regulator of intracellular Ca 2+
rise, which conducts various biological functions, including immune responses. This …
rise, which conducts various biological functions, including immune responses. This …
Cystic fibrosis transmembrane conductance regulator (ABCC7) structure
JF Hunt, C Wang, RC Ford - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Structural studies of the cystic fibrosis transmembrane conductance regulator (CFTR) are
reviewed. Like many membrane proteins, full-length CFTR has proven to be difficult to …
reviewed. Like many membrane proteins, full-length CFTR has proven to be difficult to …
Molecular modelling and molecular dynamics of CFTR
I Callebaut, B Hoffmann, P Lehn, JP Mornon - Cellular and Molecular Life …, 2017 - Springer
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the
ATP-binding cassette (ABC) transporter superfamily that functions as an ATP-gated channel …
ATP-binding cassette (ABC) transporter superfamily that functions as an ATP-gated channel …
Functional architecture of the CFTR chloride channel
P Linsdell - Molecular membrane biology, 2014 - Taylor & Francis
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR), a member of the ATP-binding cassette (ABC) family of membrane …
regulator (CFTR), a member of the ATP-binding cassette (ABC) family of membrane …
On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator
Key points Two functional abnormalities of cystic fibrosis transmembrane conductance
regulator (CFTR), a 25% reduction of the single‐channel conductance (g) and a∼ 13‐fold …
regulator (CFTR), a 25% reduction of the single‐channel conductance (g) and a∼ 13‐fold …
Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore
JJ Zhou, MS Li, J Qi, P Linsdell - Journal of General Physiology, 2010 - rupress.org
Rapid chloride permeation through the cystic fibrosis transmembrane conductance regulator
(CFTR) Cl− channel is dependent on the presence of fixed positive charges in the …
(CFTR) Cl− channel is dependent on the presence of fixed positive charges in the …