Surviving the heat: the role of macromolecular assemblies in promoting cellular shutdown
During heat shock (HS), cells orchestrate a gene expression program that promotes the
synthesis of HS proteins (HSPs) while simultaneously repressing the synthesis of other …
synthesis of HS proteins (HSPs) while simultaneously repressing the synthesis of other …
From prions to stress granules: defining the compositional features of prion-like domains that promote different types of assemblies
Stress granules are ribonucleoprotein assemblies that form in response to cellular stress.
Many of the RNA-binding proteins found in stress granule proteomes contain prion-like …
Many of the RNA-binding proteins found in stress granule proteomes contain prion-like …
[HTML][HTML] The properties and domain requirements for phase separation of the Sup35 prion protein in vivo
The Sup35 prion protein of budding yeast has been reported to undergo phase separation
to form liquid droplets both at low pH in vitro and when energy depletion decreases the …
to form liquid droplets both at low pH in vitro and when energy depletion decreases the …
Isoform-specific sequestration of protein kinase A fine-tunes intracellular signaling during heat stress
Protein kinase A (PKA) is a conserved kinase crucial for fundamental biological processes
linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as …
linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as …
Lsm7 phase-separated condensates trigger stress granule formation
Stress granules (SGs) are non-membranous organelles facilitating stress responses and
linking the pathology of age-related diseases. In a genome-wide imaging-based phenomic …
linking the pathology of age-related diseases. In a genome-wide imaging-based phenomic …
fLPS 2.0: rapid annotation of compositionally-biased regions in biological sequences
Compositionally-biased (CB) regions in biological sequences are enriched for a subset of
sequence residue types. These can be shorter regions with a concentrated bias (ie, those …
sequence residue types. These can be shorter regions with a concentrated bias (ie, those …
GraPES: The Granule Protein Enrichment Server for prediction of biological condensate constituents
Phase separation-based condensate formation is a novel working paradigm in biology,
hel** to rationalize many important cellular phenomena including the assembly of …
hel** to rationalize many important cellular phenomena including the assembly of …
Chandipura virus forms cytoplasmic inclusion bodies through phase separation and proviral association of cellular protein kinase R and stress granule protein TIA-1
Negative-strand RNA viruses form cytoplasmic inclusion bodies (IBs) representing virus
replication foci through phase separation or biomolecular condensation of viral and cellular …
replication foci through phase separation or biomolecular condensation of viral and cellular …
Comparison of biomolecular condensate localization and protein phase separation predictors
Research in the field of biochemistry and cellular biology has entered a new phase due to
the discovery of phase separation driving the formation of biomolecular condensates, or …
the discovery of phase separation driving the formation of biomolecular condensates, or …
Intrinsically disordered regions promote protein refoldability and facilitate retrieval from biomolecular condensates
Many eukaryotic proteins contain intrinsically disordered regions (IDRs) that intersperse
globular folded domains, in contrast with bacterial proteins which are typically highly …
globular folded domains, in contrast with bacterial proteins which are typically highly …